The Role of the Systemic Immune-Inflammation Index in Coronary Heart Disease: A Comprehensive Review of Thromboinflammation, Phenotypic Variability, and Clinical Implications - Takeaways - MDSpire

The Role of the Systemic Immune-Inflammation Index in Coronary Heart Disease: A Comprehensive Review of Thromboinflammation, Phenotypic Variability, and Clinical Implications

  • By

  • Mengyao Liu

  • Jiaojiao Mao

  • Xinyi Wang

  • Kaili Wang

  • Henghe Wang

  • April 28, 2026

  • 0 min

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  • 1

    Coronary heart disease (CHD) is primarily a thrombo-inflammatory disease driven by interactions among platelets, neutrophils, and lymphocytes.

  • 2

    The Systemic Immune-Inflammation Index (SII) integrates thrombosis, inflammation, and immunity, providing a composite indicator for thrombo-inflammatory burden.

  • 3

    SII demonstrates significant phenotype dependence, peaking in acute coronary syndrome (ACS) while serving as a monitoring tool in chronic coronary syndrome (CCS).

  • 4

    A three-tiered threshold system for SII aids in predicting major adverse cardiovascular events and stratifying risks in acute and chronic phases.

  • 5

    Future research should focus on validating SII's association with direct thrombotic markers and developing phenotype-adaptive risk models for improved clinical outcomes.

Original Source(s)

The Role of the Systemic Immune-Inflammation Index in Coronary Heart Disease: A Comprehensive Review of Thromboinflammation, Phenotypic Variability, and Clinical Implications

  • by Mengyao Liu, Jiaojiao Mao, Xinyi Wang, Kaili Wang, Henghe Wang

  • April 28, 2026

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