Tau Oligomers Promote Invagination of the Nuclear Lamina and Alter Chromatin Structure in Alzheimer's Disease - Takeaways - MDSpire

Tau Oligomers Promote Invagination of the Nuclear Lamina and Alter Chromatin Structure in Alzheimer's Disease

  • By

  • Shuo Yuan

  • Nicholas Essepian

  • Rebecca Roberts

  • Eliana Sherman

  • Qingbo Wang

  • Alev Erisir

  • Lulu Jiang

  • April 22, 2026

  • 0 min

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  • 1

    Alzheimer's disease is characterized by pathological β-amyloid plaques and tau neurofibrillary tangles, leading to neuronal degeneration.

  • 2

    Tau oligomers are identified as the most toxic species in Alzheimer's disease, promoting neuroinflammation and neurodegeneration.

  • 3

    Pathological tau disrupts the nuclear lamina, causing nuclear invaginations and alterations in chromatin structure.

  • 4

    Nuclear lamina disruption correlates with early tau aggregation in Alzheimer's patients and transgenic mouse models.

  • 5

    Tau oligomers induce significant nuclear intrusions, exacerbating neuronal dysfunction in Alzheimer's disease.

Original Source(s)

Tau Oligomers Promote Invagination of the Nuclear Lamina and Alter Chromatin Structure in Alzheimer's Disease

  • by Shuo Yuan, Nicholas Essepian, Rebecca Roberts, Eliana Sherman, Qingbo Wang, Alev Erisir, Lulu Jiang

  • April 22, 2026

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