Response to: “MAPSE in critical illness: from prognostic association to clinical utility” - Takeaways - MDSpire
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Authors’ response to comments on MAPSE in critical illness: translating prognostic associations into clinical practice

  • By

  • Oscar Cavefors

  • Jonatan Oras

  • October 22, 2026

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  • 1

    Reduced MAPSE alone should not trigger inotropic therapy; treatment decisions should reflect the patient’s overall hemodynamic and clinical status.

  • 2

    The study assessed MAPSE feasibility and prognostic value across a heterogeneous ICU population, viewing it as a bedside risk-stratification marker alongside other findings.

  • 3

    After adjustment for age, SAPS 3, and cardiac index, lower MAPSE remained independently associated with 90-day mortality, whereas LVEF did not.

  • 4

    MAPSE measurement was substantially more feasible than Simpson biplane LVEF measurement in this critically ill population.

  • 5

    The authors retained patients with mitral annular calcification and called for studies with prespecified etiologic strata, interaction analyses, and serial echocardiography.

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