Imbalance of Iron Homeostasis in Neuropsychiatric Conditions

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Iron is essential for brain function, participating in oxygen transport, energy metabolism, DNA synthesis, and neurotransmitter synthesis.
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Iron dyshomeostasis is linked to neuropsychiatric disorders, including Parkinson’s disease, Alzheimer’s disease, depression, and ADHD.
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Excess iron in the brain can lead to oxidative stress and mitochondrial dysfunction, contributing to neurodegenerative diseases.
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Iron deficiency affects myelination and neurotransmitter systems, increasing the risk of neurodevelopmental disorders like ADHD.
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Understanding iron homeostasis is crucial for developing new treatment strategies for neuropsychiatric conditions.

Frontiers In Psychiatry

by Mengjie Cheng, Jiazi Ma, Yong Yang, Mao Cao, Enguo Zhang, Bin Feng, Qiang Wang, Zhongjun Du
April 21, 2026

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