Growth hormone therapy after hematopoietic cell transplantation in childhood: a nationwide survey and longitudinal cohort study - Takeaways - MDSpire

Growth hormone therapy after hematopoietic cell transplantation in childhood: a nationwide survey and longitudinal cohort study

  • By

  • Maiko Shimomura

  • Hiroshi Kawaguchi

  • Eisuke Inoue

  • Reiko Kagawa

  • Satoshi Okada

  • Shohei Yamamoto

  • Maho Sato

  • Kana Washio

  • Miho Ashiarai

  • Shoji Saito

  • Akira Hayakawa

  • Yasuo Ejima

  • Hiroshi Fuji

  • Shuichi Ozono

  • Hirotoshi Sakaguchi

  • Katsuyoshi Koh

  • Koji Kato

  • Katsutsugu Umeda

  • May 20, 2026

  • 0 min

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  • 1

    Growth hormone therapy significantly improves height outcomes in childhood hematopoietic cell transplantation survivors with short stature.

  • 2

    Factors like total body irradiation and chronic graft-versus-host disease are linked to poorer height outcomes after transplantation.

  • 3

    GH responsiveness varies by transplant type, with absence of total body irradiation and female sex being favorable in allogeneic HCT.

  • 4

    GH therapy does not increase the risk of complications such as slipped capital femoral epiphysis or secondary malignancies.

  • 5

    Optimizing GH therapy and developing strategies for patients with poor expected responses are crucial for improving height outcomes.

Original Source(s)

Growth hormone therapy after hematopoietic cell transplantation in childhood: a nationwide survey and longitudinal cohort study

  • by Maiko Shimomura, Hiroshi Kawaguchi, Eisuke Inoue, Reiko Kagawa, Satoshi Okada, Shohei Yamamoto, Maho Sato, Kana Washio, Miho Ashiarai, Shoji Saito, Akira Hayakawa, Yasuo Ejima, Hiroshi Fuji, Shuichi Ozono, Hirotoshi Sakaguchi, Katsuyoshi Koh, Koji Kato, Katsutsugu Umeda

  • May 20, 2026

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