Case Study: Two Instances of Idiopathic Plasmacytic Lymphadenopathy, a Subtype of Idiopathic Multicentric Castleman Disease, Accompanied by Xanthelasma Palpebrum from a Canadian Institution - Takeaways - MDSpire

Case Study: Two Instances of Idiopathic Plasmacytic Lymphadenopathy, a Subtype of Idiopathic Multicentric Castleman Disease, Accompanied by Xanthelasma Palpebrum from a Canadian Institution

  • By

  • Andrew A. Y. Chen

  • Vivian T. Yin

  • Paula Blanco

  • Mark Trinder

  • Richard I. Crawford

  • Ryan Henrie

  • Stephen Parkin

  • Nasreen Khalil

  • Mollie Carruthers

  • Lu Zhang

  • Luke Y. C. Chen

  • February 23, 2026

  • 0 min

Share

  • 1

    Idiopathic plasmacytic lymphadenopathy (iMCD-IPL) is a newly recognized subtype of idiopathic multicentric Castleman disease.

  • 2

    Both patients in the case study were Asian women in their 50s with anemia, inflammation, and normolipemic xanthelasma palpebrum.

  • 3

    Initial suspicion of IgG4-related disease was ruled out through lymph node histology, confirming the diagnosis of iMCD-IPL.

  • 4

    Both patients showed partial response to siltuximab treatment, but their xanthelasmas did not regress.

  • 5

    Literature review indicated a potential link between Castleman disease and xanthomas, as seen in cases of unicentric Castleman disease.

Original Source(s)

Case Study: Two Instances of Idiopathic Plasmacytic Lymphadenopathy, a Subtype of Idiopathic Multicentric Castleman Disease, Accompanied by Xanthelasma Palpebrum from a Canadian Institution

  • by Andrew A. Y. Chen, Vivian T. Yin, Paula Blanco, Mark Trinder, Richard I. Crawford, Ryan Henrie, Stephen Parkin, Nasreen Khalil, Mollie Carruthers, Lu Zhang, Luke Y. C. Chen

  • February 23, 2026

Related Content

VEXAS Syndrome for the laboratory physician: a case report

Multimodal management of late-stage Bockenheimer disease complicated by severe anemia and coagulopathy: a case report

Case Report: Atypical hepatobiliary manifestations associated with erythrocyte membrane instability in glucose transporter type 1 deficiency syndrome