Complement receptor 2 downregulation is associated with mortality in Staphylococcus aureus sepsis in both mice and humans - Takeaways - MDSpire
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Downregulation of Complement Receptor 2 Correlates with Increased Mortality in Staphylococcus aureus Sepsis in Mice and Humans

  • By

  • Pradeep Kumar Kopparapu

  • Meghshree Deshmukh

  • Santhilal Subhash

  • Majd Mohammad

  • Zhicheng Hu

  • Anders Jarneborn

  • Muhammad Arif

  • Marcela Pekna

  • Lars Ljungström

  • Gunnar Jacobsson

  • Ola Grimsholm

  • Tao Jin

  • July 9, 2026

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  • 1

    Complement receptor 2 (CR2) downregulation is significantly associated with increased mortality in Staphylococcus aureus sepsis in both mice and humans.

  • 2

    The study identified 16 candidate genes through transcriptomic analysis that distinguished survivors from fatal cases in a murine model of sepsis.

  • 3

    CR2 expression levels were found to correlate with disease severity and were independent of complement factor 3, TLR2, and TNF-α.

  • 4

    B-cell depletion and CR2 downregulation occurred progressively in infected mice, indicating a potential link to immune dysregulation.

  • 5

    The findings suggest that CR2 downregulation may serve as a candidate biomarker for severe infection and mortality in sepsis.

Original Source(s)

Complement receptor 2 downregulation is associated with mortality in Staphylococcus aureus sepsis in both mice and humans

  • by Pradeep Kumar Kopparapu, Meghshree Deshmukh, Santhilal Subhash, Majd Mohammad, Zhicheng Hu, Anders Jarneborn, Muhammad Arif, Marcela Pekna, Lars Ljungström, Gunnar Jacobsson, Ola Grimsholm, Tao Jin

  • July 9, 2026

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