Inflammatory bowel disease (IBD) is associated with increased intestinal extrachromosomal circular DNA: an emerging biomarker for IBD type and activity - Takeaways - MDSpire

Inflammatory bowel disease (IBD) is associated with increased intestinal extrachromosomal circular DNA: an emerging biomarker for IBD type and activity

  • By

  • Valentina Petito

  • Daniela Gerovska

  • Antonia Piazzesi

  • Federica di Vincenzo

  • Alessandra Russo

  • Laura Turchini

  • Letizia Masi

  • Valeria Emoli

  • Elisabetta Tabolacci

  • Maria Cristina Giustiniani

  • Tommaso Mazza

  • Lucrezia Laterza

  • Alfredo Papa

  • Loris R Lopetuso

  • Lorenza Putignani

  • Antonio Gasbarrini

  • Marcos J Araúzo-Bravo

  • Franco Scaldaferri

  • December 29, 2025

  • 0 min

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  • 1

    Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn's disease, characterized by chronic intestinal inflammation.

  • 2

    Patients with IBD exhibit significantly higher levels of extrachromosomal circular DNA (eccDNA) compared to healthy controls.

  • 3

    Active ulcerative colitis patients show increased eccDNA production compared to those in remission.

  • 4

    Specific gene fragments in eccDNA are enriched in IBD patients, suggesting potential as biomarkers for disease activity.

  • 5

    The study proposes eccDNA as a promising tool for predicting disease type and activity in IBD patients.

Original Source(s)

Inflammatory bowel disease (IBD) is associated with increased intestinal extrachromosomal circular DNA: an emerging biomarker for IBD type and activity

  • by Valentina Petito, Daniela Gerovska, Antonia Piazzesi, Federica di Vincenzo, Alessandra Russo, Laura Turchini, Letizia Masi, Valeria Emoli, Elisabetta Tabolacci, Maria Cristina Giustiniani, Tommaso Mazza, Lucrezia Laterza, Alfredo Papa, Loris R Lopetuso, Lorenza Putignani, Antonio Gasbarrini, Marcos J Araúzo-Bravo, Franco Scaldaferri

  • December 29, 2025

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