B-Cell Subset Representation Predicts SARS-CoV-2 Vaccine Response in Solid Organ Transplant Recipients - Takeaways - MDSpire

B-Cell Subset Representation Predicts SARS-CoV-2 Vaccine Response in Solid Organ Transplant Recipients

  • By

  • James J Knox

  • Ingi Lee

  • Emily A Blumberg

  • Aaron M Rosenfeld

  • Wenzhao Meng

  • Fang Liu

  • Charlotte Kearns

  • Una O’Doherty

  • Abraham Shaked

  • Kim M Olthoff

  • Eline T Luning Prak

  • June 3, 2025

  • 0 min

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  • 1

    Solid organ transplant recipients (SOTRs) experience increased morbidity due to chronic immunosuppression affecting immune competence.

  • 2

    B-cell subset analysis identified three distinct groups in SOTRs correlating with serologic responses to SARS-CoV-2 vaccination.

  • 3

    Group 1 SOTRs had naive-dominant B-cell pools and serologic responses similar to healthcare workers, indicating better immune competence.

  • 4

    Group 3 SOTRs exhibited lymphopenia and poor serologic responses, highlighting significant B-cell impairment.

  • 5

    The study suggests B-cell classification could aid in risk stratification and evaluation of immunocompetence in SOTRs.

Original Source(s)

B-Cell Subset Representation Predicts SARS-CoV-2 Vaccine Response in Solid Organ Transplant Recipients

  • by James J Knox, Ingi Lee, Emily A Blumberg, Aaron M Rosenfeld, Wenzhao Meng, Fang Liu, Charlotte Kearns, Una O’Doherty, Abraham Shaked, Kim M Olthoff, Eline T Luning Prak

  • June 3, 2025

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