Investigators developed US-CRS 2.0 using registry data from 33,097 adult heart transplant candidates to predict 6-week mortality without transplantation.
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In the test data set, the simpler US-CRS 2.0 model had a mean area under the receiver operating characteristic curve of 0.807, compared with 0.693 for the existing 6-status system.
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In historical match-run analyses, observed 6-week mortality among candidates ranked first was 16% with the proposed 6-status US-CRS approach and 23% with national US-CRS ranking, versus 11% under the
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The proposed approaches changed candidate rankings, prioritizing more candidates from racial and ethnic minority groups while reducing priority for candidates with blood type O and those using durable
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The score overestimated mortality among candidates at highest predicted risk, and the authors said further simulation was needed before implementation.
An aortic dissection occurs when a tear develops in the inner layer of the aorta, the body’s largest artery. Blood can force its way between layers of the vessel wall, compromising circulation to vital organs or causing catastrophic internal bleeding.
