Evaluating glycolysis-associated biomarkers for radiotherapy sensitivity in head and neck squamous cancer

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The study developed a glycolysis-associated radiosensitivity index (RI) to predict radiotherapy sensitivity in head and neck squamous cell carcinoma (HNSC).
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Low glycolytic activity correlates with improved overall survival in HNSC patients post-radiotherapy, while high activity is linked to radio-resistance.
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The RI successfully stratified patients into radiosensitive (RS) and radio-resistant (RR) groups, with RS tumors showing higher immune cell infiltration.
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High-glycolysis tumors exhibited diminished immune cell infiltration, particularly a lack of CD8+ T cells, indicating potential immune evasion.
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In vitro validation confirmed that radioresistant CAL-27IR cells had elevated glycolytic activity and upregulated key genes associated with the RI.

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