Association between region-specific epicardial adipose tissue and CT-derived fractional flow reserve-defined myocardial ischemia: a retrospective coronary CTA study stratified by hypertension and type 2 diabetes mellitus - Takeaways - MDSpire

Association between region-specific epicardial adipose tissue and CT-derived fractional flow reserve-defined myocardial ischemia: a retrospective coronary CTA study stratified by hypertension and type 2 diabetes mellitus

  • By

  • Zheng Wang

  • Yunting Hu

  • Zuoqin Li

  • Xiang Wang

  • June 17, 2026

  • 0 min

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  • 1

    Epicardial adipose tissue (EAT) is linked to coronary atherosclerosis and myocardial ischemia, particularly in patients with hypertension and type 2 diabetes mellitus.

  • 2

    The study analyzed 576 participants, revealing that ischemic subgroups had greater EAT thickness compared to controls, especially in the left atrioventricular groove.

  • 3

    LAVG-EAT thickness was independently associated with myocardial ischemia, with an odds ratio of 1.41, indicating its potential as a risk marker.

  • 4

    Adding LAVG-EAT to clinical models improved discrimination for myocardial ischemia, enhancing predictive accuracy beyond conventional variables.

  • 5

    The findings suggest that region-specific EAT metrics, particularly LAVG-EAT, may serve as practical adjuncts for ischemia identification in at-risk patients.

Original Source(s)

Association between region-specific epicardial adipose tissue and CT-derived fractional flow reserve-defined myocardial ischemia: a retrospective coronary CTA study stratified by hypertension and type 2 diabetes mellitus

  • by Zheng Wang, Yunting Hu, Zuoqin Li, Xiang Wang

  • June 17, 2026

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