Bone marrow adipoq-lineage cells in regulating the bone and marrow microenvironment: identities, functions, and mechanisms - Takeaways - MDSpire
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Regulation of Bone and Marrow Microenvironment by Adipoq-Lineage Cells: Characteristics, Roles, and Mechanisms

  • By

  • Chunyan Zhang

  • Xiaohui Gu

  • Yuyan Xiang

  • Chanchan Zheng

  • Lei Yang

  • Jianquan Chen

  • August 13, 2026

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  • 1

    Bone marrow Adipoq-lineage cells include all cells that have expressed Adipoq and their descendants, playing critical roles in various physiological processes.

  • 2

    Adipoq-lineage cells exhibit considerable heterogeneity, including true adipogenic precursors (MALPs) and bipotent adipo-osteoprogenitors (Adipoq+Osx+ cells).

  • 3

    MALPs primarily function as lineage-restricted adipo-progenitors, contributing to marrow adipogenesis but showing minimal potential for osteoblast differentiation.

  • 4

    Adipoq+Osx+ cells are located in the endosteal niche and significantly participate in the formation of both osteoblasts and adipocytes.

  • 5

    The review emphasizes the need for further research to explore the regulatory mechanisms and functional characteristics of Adipoq-lineage cells.

Original Source(s)

Bone marrow adipoq-lineage cells in regulating the bone and marrow microenvironment: identities, functions, and mechanisms

  • by Chunyan Zhang, Xiaohui Gu, Yuyan Xiang, Chanchan Zheng, Lei Yang, Jianquan Chen

  • August 13, 2026

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