Steroid alterations in Cushing’s disease persist after remission: ACTH-driven steroid changes dissociate from mood-regulatory neurosteroids - Takeaways - MDSpire

Steroid alterations in Cushing’s disease persist after remission: ACTH-driven steroid changes dissociate from mood-regulatory neurosteroids

  • By

  • Sebnem Burhan

  • Ebubekir Akpinar

  • Sevim Eyupoglu

  • Ayhan Bingol

  • Merve Korkmaz Yilmaz

  • Aslihan Pekmezci

  • Ebru Turgal

  • Huseyin Sehit Burhan

  • Mutlu Niyazoglu

  • Esra Suheda Hatipoglu

  • July 2, 2026

  • 0 min

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  • 1

    Cushing's disease (CD) is linked to high rates of depression and anxiety, which often persist after biochemical remission.

  • 2

    A study of 37 CD patients identified five neurosteroids (NS) with altered levels, including elevated 4-androstenedione and corticosterone.

  • 3

    Despite remission, neurosteroid alterations persisted, with 7-OH-pregnenolone levels increasing significantly.

  • 4

    Mood symptoms in CD did not correlate with cortisol or ACTH levels, indicating a dissociation between steroid alterations and mood.

  • 5

    The findings suggest that cortisol reduction alone may not adequately address psychiatric symptoms in CD patients.

Original Source(s)

Steroid alterations in Cushing’s disease persist after remission: ACTH-driven steroid changes dissociate from mood-regulatory neurosteroids

  • by Sebnem Burhan, Ebubekir Akpinar, Sevim Eyupoglu, Ayhan Bingol, Merve Korkmaz Yilmaz, Aslihan Pekmezci, Ebru Turgal, Huseyin Sehit Burhan, Mutlu Niyazoglu, Esra Suheda Hatipoglu

  • July 2, 2026

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