Effective Management of Pre-Extensively Drug-Resistant Tuberculous Meningoencephalomyelitis in Pregnant Patients Using a Bedaquiline and Delamanid Treatment Approach: A Case Study - Takeaways - MDSpire

Effective Management of Pre-Extensively Drug-Resistant Tuberculous Meningoencephalomyelitis in Pregnant Patients Using a Bedaquiline and Delamanid Treatment Approach: A Case Study

  • By

  • Qi Nie

  • Yuan Liu

  • Fan Xiao

  • Yong Zhou

  • Tingting Fu

  • Lijuan Zheng

  • Dongmei Huang

  • Qiuping Tang

  • Ting Liu

  • Lixuan Tao

  • January 30, 2026

  • 0 min

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  • 1

    Managing pre-XDR-TBMEM in pregnant patients poses significant challenges due to limited treatment options and concerns over fetal safety.

  • 2

    Bedaquiline and delamanid have emerged as effective treatment options for drug-resistant tuberculosis during pregnancy.

  • 3

    A multidisciplinary approach was crucial in the successful management of a pregnant patient with pre-XDR-TBMEM and TB-Sepsis.

  • 4

    The patient experienced a Neuro-IRIS crisis, which was managed with CSF drainage and intrathecal dexamethasone.

  • 5

    The mother and infant had favorable outcomes, with the infant showing no signs of tuberculosis at birth.

Original Source(s)

Effective Management of Pre-Extensively Drug-Resistant Tuberculous Meningoencephalomyelitis in Pregnant Patients Using a Bedaquiline and Delamanid Treatment Approach: A Case Study

  • by Qi Nie, Yuan Liu, Fan Xiao, Yong Zhou, Tingting Fu, Lijuan Zheng, Dongmei Huang, Qiuping Tang, Ting Liu, Lixuan Tao

  • January 30, 2026

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