Efficacy and safety of sini powder combined with Xiaoxianxiong decoction for adolescent depression with liver qi stagnation and phlegm-heat obstruction syndrome: a randomized controlled trial - Takeaways - MDSpire

Efficacy and safety of sini powder combined with Xiaoxianxiong decoction for adolescent depression with liver qi stagnation and phlegm-heat obstruction syndrome: a randomized controlled trial

  • By

  • Ruiyu Lin

  • Yangzhen Liu

  • Juncheng Li

  • Jia Gao

  • Liting He

  • Shanying Huang

  • June 12, 2026

  • 0 min

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  • 1

    The study assessed the efficacy and safety of Sini San combined with Xiaoxianxiong Tang for treating adolescent depression with liver qi stagnation and phlegm-heat.

  • 2

    Sixty adolescents aged 12-18 with moderate depression were randomly assigned to receive either TCM therapy plus counseling or counseling alone for 8 weeks.

  • 3

    At 8 weeks, the TCM group showed significantly lower CDRS-R and TCM syndrome scores, higher PedsQL scores, and a higher clinical effective rate compared to the control group.

  • 4

    The TCM group reported 6.7% mild gastrointestinal discomfort, with no serious adverse events noted during the study.

  • 5

    The findings are preliminary and cannot support broad clinical promotion due to the small sample size and lack of double-blinding and placebo control.

Original Source(s)

Efficacy and safety of sini powder combined with Xiaoxianxiong decoction for adolescent depression with liver qi stagnation and phlegm-heat obstruction syndrome: a randomized controlled trial

  • by Ruiyu Lin, Yangzhen Liu, Juncheng Li, Jia Gao, Liting He, Shanying Huang

  • June 12, 2026

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