Development and internal validation of a risk prediction model for ipsilateral upper-limb lymphedema following breast cancer surgery - Takeaways - MDSpire

Development and internal validation of a risk prediction model for ipsilateral upper-limb lymphedema following breast cancer surgery

  • By

  • Yufei Fan

  • Gaofeng Yang

  • Yumeng Zeng

  • Yanfei Lu

  • Fan Feng

  • Xiudi Wang

  • June 3, 2026

  • 0 min

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  • 1

    A predictive nomogram for breast cancer-related lymphedema (BCRL) was developed and internally validated using data from 234 patients.

  • 2

    The final model included four significant predictors: surgery type, pectoral nodes dissection, number of harvested lymph nodes, and N stage.

  • 3

    Breast-conserving surgery was linked to a lower risk of BCRL, while pectoral nodes dissection and higher N stage increased risk.

  • 4

    The nomogram demonstrated excellent discriminative ability with an AUC of 0.964, indicating strong prediction performance.

  • 5

    Pending external validation, the nomogram serves as a supportive tool for risk stratification and early intervention in BCRL.

Original Source(s)

Development and internal validation of a risk prediction model for ipsilateral upper-limb lymphedema following breast cancer surgery

  • by Yufei Fan, Gaofeng Yang, Yumeng Zeng, Yanfei Lu, Fan Feng, Xiudi Wang

  • June 3, 2026

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