Metabolic and Structural Alterations Linked to Mice's Vulnerability to Primary Echinostoma caproni Infections - Takeaways - MDSpire

Metabolic and Structural Alterations Linked to Mice's Vulnerability to Primary Echinostoma caproni Infections

  • By

  • Emma Fiallos

  • Paola Cociancic

  • José Guillermo Esteban

  • Carla Muñoz-Antoli

  • Rafael Toledo

  • April 21, 2026

  • 0 min

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  • 1

    Echinostoma caproni infections in mice lead to significant metabolic and immunological changes, impacting host susceptibility and pathology.

  • 2

    Infection results in upregulation of proteins related to oxidative phosphorylation and inflammation, indicating heightened oxidative stress.

  • 3

    Downregulation of proteins associated with fatty acid metabolism and epithelial integrity suggests compromised intestinal homeostasis.

  • 4

    The study reveals an imbalance in immune response, with increased antimicrobial peptides but reduced eosinophil and neutrophil effectors.

  • 5

    Findings enhance understanding of host susceptibility to helminths and may inform future therapeutic strategies against intestinal infections.

Original Source(s)

Metabolic and Structural Alterations Linked to Mice's Vulnerability to Primary Echinostoma caproni Infections

  • by Emma Fiallos, Paola Cociancic, José Guillermo Esteban, Carla Muñoz-Antoli, Rafael Toledo

  • April 21, 2026

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