Photon-counting computed tomography in esophageal cancer: correlation of iodine concentration with histopathology and treatment response to neoadjuvant radiochemotherapy - Takeaways - MDSpire

Photon-counting computed tomography in esophageal cancer: correlation of iodine concentration with histopathology and treatment response to neoadjuvant radiochemotherapy

  • By

  • Nina Pauline Haag

  • Pascal Bodin

  • Jan Robert Kröger

  • Julius Henning Niehoff

  • Saher Saeed

  • Berthold Gerdes

  • Raihanatou Ina Danebrock

  • Ulrich Klaus Fetzner

  • Jan Borggrefe

  • Andreas Wienke

  • Alexey Surov

  • May 23, 2025

  • 0 min

Share

  • 1

    Esophageal cancer is a prevalent and aggressive malignancy, with neoadjuvant radiochemotherapy being the standard treatment for advanced cases.

  • 2

    Photon-counting computed tomography (PCCT) enhances tumor characterization by quantifying iodine concentration, reflecting tumor vascularity and treatment response.

  • 3

    The study included 105 patients with locally advanced esophageal cancer, assessing the correlation between iodine concentration and histopathological features.

  • 4

    Normalized iodine concentration was calculated to account for physiological variability, aiding in the evaluation of treatment response to neoadjuvant therapy.

  • 5

    Statistical analysis demonstrated the potential of iodine concentration as a predictor of treatment response, with significant correlations to tumor characteristics.

Original Source(s)

Photon-counting computed tomography in esophageal cancer: correlation of iodine concentration with histopathology and treatment response to neoadjuvant radiochemotherapy

  • by Nina Pauline Haag, Pascal Bodin, Jan Robert Kröger, Julius Henning Niehoff, Saher Saeed, Berthold Gerdes, Raihanatou Ina Danebrock, Ulrich Klaus Fetzner, Jan Borggrefe, Andreas Wienke, Alexey Surov

  • May 23, 2025

Related Content

Early prediction of immune checkpoint inhibitor-related pneumonitis in advanced non-small cell lung cancer based on primary tumor Delta-radiomics features

TOPOS: target organ prediction on scout views for automated CT scan planning

Reduced-Dose Radiation Shows Durable Control

Single-arm cohort findings contrast with interim results from NRG-HN005, underscoring ongoing uncertainty around treatment deintensification.