A Comprehensive Review of Extragenital Lichen Sclerosus in the Medical Literature - Takeaways - MDSpire

A Comprehensive Review of Extragenital Lichen Sclerosus in the Medical Literature

  • By

  • Marta Kasprowicz-Furmańczyk

  • Ilona Tadulewicz

  • Agnieszka Markiewicz

  • Agnieszka Owczarczyk-Saczonek

  • March 19, 2026

  • 0 min

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  • 1

    Extragenital lichen sclerosus (ELS) affects 15–20% of lichen sclerosus patients and is rarely isolated.

  • 2

    ELS lesions are usually asymptomatic or mildly pruritic, commonly affecting the neck, trunk, and upper extremities.

  • 3

    Diagnosis of ELS is primarily clinical, confirmed by histopathology, with skin biopsy as the gold standard.

  • 4

    High-potency topical corticosteroids are the first-line treatment for ELS, with phototherapy and methotrexate for refractory cases.

  • 5

    Unlike genital lichen sclerosus, ELS is not associated with an increased risk of squamous cell carcinoma.

Original Source(s)

A Comprehensive Review of Extragenital Lichen Sclerosus in the Medical Literature

  • by Marta Kasprowicz-Furmańczyk, Ilona Tadulewicz, Agnieszka Markiewicz, Agnieszka Owczarczyk-Saczonek

  • March 19, 2026

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