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1
Researchers analyzed 148,640 Reddit posts and comments from 38,936 users across 27 communities between May 2021 and December 2025.
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2
The analysis identified 13,589 users reporting current retatrutide use, and 7,823 users reported at least 1 mapped symptom after prespecified weight-related terms were excluded.
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3
The most frequently reported symptoms included increased appetite, fatigue, increased energy, nausea, food craving, insomnia, and increased heart rate.
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4
Compared descriptively with prior semaglutide and tirzepatide social media analyses, retatrutide discussions featured more appetite, general-system, muscle-related, sleep, and heart-rate terms.
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5
Because product identity, dose, and other clinical details could not be verified, the analysis cannot establish symptom incidence, causality, dose-response, or comparative safety.
