Physiological correlates of pain in preterm infants: evidence from a meta-analytic approach - Takeaways - MDSpire

Physiological correlates of pain in preterm infants: evidence from a meta-analytic approach

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1

This meta-analysis reviewed 15 studies involving 1,273 preterm infants to identify physiological indicators of pain.
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Painful procedures in preterm infants resulted in significant increases in heart rate and cortisol levels.
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Decreases in heart rate variability, oxygen saturation, melatonin, and cerebral oxygenation were also observed.
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Subgroup analyses indicated the strongest effects on cardiorespiratory parameters during painful procedures.
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The findings suggest integrating physiological indicators into neonatal pain assessment may improve pain management.