Accelerometer-Based Activity Sensing by an Insertable Cardiac Monitor In Ambulatory Patients: A Subanalysis of LUX-Dx TRENDS (LUX-Dx Heart Failure Sensors in an Insertable Cardiac Monitor System Clinical Study) - Takeaways - MDSpire
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Activity Monitoring With an Insertable Cardiac Monitor in Ambulatory Patients: Subanalysis of the LUX-Dx TRENDS Clinical Study of Heart Failure Sensors

  • By

  • ANDREW J. SAUER

  • E. MATTHEW QUIN

  • KARAN BHALLA

  • SASHI ADIGOPULA

  • BIN MI

  • EMILY THOMPSON

  • DEEPA MAHAJAN

  • MING DUANMU

  • CRAIG M. STOLEN

  • MOLLY E. KUPFER

  • ALYSIA ROSNER

  • SELÇUK ADABAG

  • SCOTT D. SOLOMON

  • ELAINE Y. WAN

  • October 11, 2026

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  • 1

    The LUX-Dx TRENDS exercise substudy includes 104 ambulatory patients with New York Heart Association class II or III heart failure at 26 US sites.

  • 2

    Subcutaneous accelerometer activity signals increase by an estimated 33.7 mG per 1-mph increase in treadmill walking speed in dataset 1 and 32.3 mG in dataset 2.

  • 3

    In dataset 2, device activity classification shows near-perfect agreement with the prespecified reference standard (κ = 0.971; 95% CI, 0.947–0.985).

  • 4

    In dataset 2, sensitivity is 0.974, specificity is 0.994, positive predictive value is 0.991, and negative predictive value is 0.982 using the primary reference standard.

  • 5

    The algorithm continues to meet its prespecified performance goal of κ > 0.8 when sensitivity analyses classify treadmill walking at 0.7 mph as either active or inactive.

Original Source(s)

Accelerometer-Based Activity Sensing by an Insertable Cardiac Monitor In Ambulatory Patients: A Subanalysis of LUX-Dx TRENDS (LUX-Dx Heart Failure Sensors in an Insertable Cardiac Monitor System Clinical Study)

  • by ANDREW J. SAUER, E. MATTHEW QUIN, KARAN BHALLA, SASHI ADIGOPULA, BIN MI, EMILY THOMPSON, DEEPA MAHAJAN, MING DUANMU, CRAIG M. STOLEN, MOLLY E. KUPFER, ALYSIA ROSNER, SELÇUK ADABAG, SCOTT D. SOLOMON, ELAINE Y. WAN

  • October 11, 2026

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