Triglyceride-glucose index and nocturnal oxygenation impairment in patients with obstructive sleep apnea

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The study examined the association between the triglyceride-glucose (TyG) index and nocturnal oxygenation in obstructive sleep apnea (OSA) patients.
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Higher TyG levels were found in patients with severe nocturnal oxygen desaturation (lowest SpO2 <80%) and severe AHI-defined OSA (AHI ≥30 events/h).
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TyG positively correlated with apnea-hypopnea index (AHI) and time spent below 90% oxygen saturation (CT90), while negatively correlating with mean and lowest SpO2.
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In adjusted models, TyG remained associated with lowest SpO2 <80% and AHI ≥30 events/h, although the association with lowest SpO2 was weakened after adjusting for AHI.
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The findings suggest that TyG may serve as a metabolic marker for assessing risk in OSA, but it cannot replace formal sleep monitoring.

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