The Effect of Initial Versus Sequential Chemoradiotherapy on Survival in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma

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The study analyzed 91 patients with locally advanced esophageal squamous cell carcinoma receiving either upfront or salvage definitive chemoradiotherapy.
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The salvage group achieved a higher overall objective remission rate of 68.29% compared to 26.00% in the upfront group (P < 0.001).
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Progression-free survival was significantly longer in the salvage group at 20.3 months versus 6.4 months in the upfront group (P = 0.001).
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The median overall survival was 42.2 months for the salvage group, significantly longer than 15.9 months for the upfront group (P = 0.001).
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Salvage DCRT significantly improved survival outcomes, suggesting its potential as a new treatment paradigm for locally advanced unresectable ESCC.

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