Maternal TSH and FT4 changes during pregnancy as risk factors for preeclampsia in euthyroid women - Takeaways - MDSpire

Maternal TSH and FT4 changes during pregnancy as risk factors for preeclampsia in euthyroid women

  • By

  • Jianxia Lin

  • Yili Zhang

  • Yu Meng

  • Yan Su

  • Mengfan Song

  • May 26, 2026

  • 0 min

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  • 1

    This study investigates the relationship between changes in FT4 and TSH levels during pregnancy and preeclampsia risk in euthyroid women.

  • 2

    TSH changes exhibited a J-shaped nonlinear association with preeclampsia risk, while FT4 changes showed a linear negative association.

  • 3

    The Complete Decompensation group, with significant TSH increases and FT4 decreases, had the highest preeclampsia risk at 2.7%.

  • 4

    Population-attributable risk analysis indicated that 21.6% of preeclampsia cases were linked to specific thyroid function change patterns.

  • 5

    The study concludes that significant TSH increases combined with FT4 decreases during pregnancy are associated with higher preeclampsia risk.

Original Source(s)

Maternal TSH and FT4 changes during pregnancy as risk factors for preeclampsia in euthyroid women

  • by Jianxia Lin, Yili Zhang, Yu Meng, Yan Su, Mengfan Song

  • May 26, 2026

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