Analytical agreement and clinical interchangeability of routine complete blood count parameters between the Atellica HEMA 580 and Sysmex XN-1000 analyzers: a CLSI EP09c study - Takeaways - MDSpire

Analytical agreement and clinical interchangeability of routine complete blood count parameters between the Atellica HEMA 580 and Sysmex XN-1000 analyzers: a CLSI EP09c study

  • By

  • Quang Tung Nguyen

  • Van Tuan Pham

  • Chi Thanh Nguyen

  • Phuc Minh Hoang Nguyen

  • Dieu Huong Nguyen

  • Huong Lan Tong

  • July 2, 2026

  • 0 min

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  • 1

    The study evaluated analytical agreement between Atellica HEMA 580 and Sysmex XN-1000 analyzers using 100 residual K₂EDTA whole-blood samples.

  • 2

    Strong analytical agreement was found for RBC, HGB, WBC, and PLT-I, with correlation coefficients exceeding 0.98 for these parameters.

  • 3

    MCV and RDW-CV showed analyzer-dependent differences, with MCV exceeding allowable bias limits and RDW-CV demonstrating lower correlation.

  • 4

    Bland–Altman analysis confirmed small mean bias for RBC and HGB, while wider limits of agreement were observed for WBC and PLT-I.

  • 5

    The Atellica HEMA 580 can be applied in clinical practice, but caution is advised when interpreting MCV and RDW-CV results across platforms.

Original Source(s)

Analytical agreement and clinical interchangeability of routine complete blood count parameters between the Atellica HEMA 580 and Sysmex XN-1000 analyzers: a CLSI EP09c study

  • by Quang Tung Nguyen, Van Tuan Pham, Chi Thanh Nguyen, Phuc Minh Hoang Nguyen, Dieu Huong Nguyen, Huong Lan Tong

  • July 2, 2026

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