Intra-cavitary radiotherapy for surgically resected brain metastases: a comprehensive analysis including an individual patient data meta-analysis of intraoperative radiotherapy (IORT) and brachytherapy (IBT)

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Brain metastases are the most common intracranial malignancy in adults, affecting approximately 2% of all cancer patients.
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Postoperative radiotherapy is essential for improving local control of brain metastases, as surgery alone leads to high recurrence rates.
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Intraoperative radiotherapy (IORT) and intracavitary brachytherapy (IBT) deliver localized radiation, showing promising local control rates of 85–96%.
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This meta-analysis evaluates the efficacy and safety of IORT and IBT in patients with surgically resected brain metastases.
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The study includes 23 articles with 858 patients, assessing outcomes like local control, overall survival, and treatment-related toxicity.

Journal Of Neuro-Oncology

by Alexandru Guranda, Erdem Güresir, Arne Mathias Ruder, Frank Anton Giordano, Johannes Wach
September 17, 2025

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