Wegovy and Possible Vision Risk
Higher dose weight loss injectable demonstrates nearly five times higher ischaemic optic neuropathy risk than other semaglutide GLP-1 agonists
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1
Semaglutide, a GLP-1RA, may be linked to ischaemic optic neuropathy (ION), raising concerns for clinicians and ophthalmologists.
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2
An analysis of over 30 million FDA adverse event reports identified semaglutide as the only GLP-1RA significantly associated with ION.
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3
Wegovy, the higher-dose semaglutide for obesity, showed the strongest association with ION, nearly five times higher than Ozempic.
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4
Sex-specific differences were noted, with men on Wegovy having higher ION reporting odds, while Ozempic cases were more common in women.
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5
No ION signal was found with tirzepatide or comparator drugs, indicating a need for further research on semaglutide's ocular effects.
