Queries regarding the two papers each reporting on 1000 essential thrombocythemia patients in BCJ

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The Florence and Mayo Clinic groups each studied 1000 essential thrombocythemia patients, providing extensive data on the disease.
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Questions were raised about triple negative patients lacking clonal markers and their clinical and hematologic characteristics.
3

Florence cohort's triple negative patients exhibited better prognosis for myelofibrosis, leukemia, and thrombosis-free survival.
4

The authors were asked to explore reasons for the differing prognoses between the Florence and Mayo Clinic triple negative patients.
5

The findings from both cohorts may indicate variations in the natural course of triple negative essential thrombocythemia.

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