Targeting macrophages in liver fibrosis

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Fibrosis results from excessive ECM deposition due to chronic tissue injury, leading to organ dysfunction, particularly in the liver.
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Macrophages play a central role in the fibrotic liver, influencing inflammation, immune regulation, and tissue repair.
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Liver fibrosis is potentially reversible, with macrophage reprogramming linked to improved efferocytosis and reduced inflammation.
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Current therapeutic strategies are shifting towards promoting macrophage pro-resolution programs rather than inhibiting monocyte recruitment.
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Macrophage heterogeneity and plasticity are crucial for their roles in fibrogenesis and fibrosis resolution, making them key therapeutic targets.

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