Occludin takes centre stage in HIV defence and stroke - Takeaways - MDSpire

Occludin takes centre stage in HIV defence and stroke

  • By

  • Amber Douglass

  • Clarissa Halpern

  • Sanjay B Maggirwar

  • January 10, 2026

  • 0 min

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  • 1

    HIV increases the risk of cerebrovascular disorders, including ischemic stroke, even in patients on effective antiretroviral therapy.

  • 2

    Occludin is proposed to actively regulate immune responses and barrier permeability in the blood-brain barrier, influencing HIV susceptibility.

  • 3

    Loss of occludin disrupts mitochondrial antiviral signaling, leading to increased HIV replication and worsened ischemic stroke outcomes.

  • 4

    The study highlights the role of mitochondrial dysfunction in both HIV infection and ischemic stroke, affecting immune responses.

  • 5

    Therapeutic strategies enhancing occludin function may improve blood-brain barrier integrity and immune responses in HIV-infected individuals.

Original Source(s)

Occludin takes centre stage in HIV defence and stroke

  • by Amber Douglass, Clarissa Halpern, Sanjay B Maggirwar

  • January 10, 2026

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