Vitamin D-related genetic variants as predictive biomarkers for breast cancer in Jordanian women - Takeaways - MDSpire

Vitamin D-related genetic variants as predictive biomarkers for breast cancer in Jordanian women

  • By

  • Laith N. Al-Eitan

  • Maryam K. Alasmar

  • Mohammed S. Alorjani

  • Lina M. Sarhan

  • Sakher S. Sammour

  • Farah N. Aladwan

  • Hadil A. Al Refai

  • Sara S. Hasanat

  • Mira S. Quran

  • Mansour A. Alghamdi

  • May 28, 2026

  • 0 min

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  • 1

    The study investigates the association between genetic variants in vitamin D metabolism and breast cancer risk in Jordanian women.

  • 2

    CYP2R1 and CYP27B1 polymorphisms showed significant associations with reduced breast cancer risk in the studied population.

  • 3

    No significant associations were found for CYP2R1 rs10741657, CYP24A1 rs2248359, or DBP variants in relation to breast cancer.

  • 4

    The study included 600 female participants, with 300 diagnosed with breast cancer and 300 healthy controls.

  • 5

    Further research is recommended to validate the protective influence of specific genotypes against breast cancer.

Original Source(s)

Vitamin D-related genetic variants as predictive biomarkers for breast cancer in Jordanian women

  • by Laith N. Al-Eitan, Maryam K. Alasmar, Mohammed S. Alorjani, Lina M. Sarhan, Sakher S. Sammour, Farah N. Aladwan, Hadil A. Al Refai, Sara S. Hasanat, Mira S. Quran, Mansour A. Alghamdi

  • May 28, 2026

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