Identification of Gut Microbiome Signatures and Metabolites Associated With Albuminuria in Type 2 Diabetes - Takeaways - MDSpire

Identification of Gut Microbiome Signatures and Metabolites Associated With Albuminuria in Type 2 Diabetes

  • By

  • Yi-Ting Lin

  • Sergi Sayols-Baixeras

  • Tiscar Graells

  • Koen F Dekkers

  • Gabriel Baldanzi

  • Diem Nguyen

  • Anders Larsson

  • Tobias Rudholm Feldreich

  • Nynne Nielsen

  • Aron C Eklund

  • Jacob B Holm

  • H Bjørn Nielsen

  • Göran Bergström

  • J Gustav Smith

  • Andrei Malinovschi

  • Gunnar Engström

  • Marju Orho-Melander

  • Tove Fall

  • Johan Ärnlöv

  • August 14, 2025

  • 0 min

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  • 1

    The study analyzed gut microbiome profiles and plasma metabolites in 752 individuals with type 2 diabetes to investigate their relationship with albuminuria.

  • 2

    Three gut microbial species were identified as associated with albuminuria: Sellimonas intestinalis, Eggerthellales sp., and Ellagibacter isourolithinifaciens.

  • 3

    The findings were replicated in a prediabetic population of 3423 participants, confirming the association of specific microbial species with albuminuria.

  • 4

    A total of 36 annotated metabolites were linked to the three albuminuria-signature species, suggesting their role in metabolic regulation.

  • 5

    The study highlights the complex interplay between gut microbiome, plasma metabolites, and albuminuria in type 2 diabetes, emphasizing the need for further research.

Original Source(s)

Identification of Gut Microbiome Signatures and Metabolites Associated With Albuminuria in Type 2 Diabetes

  • by Yi-Ting Lin, Sergi Sayols-Baixeras, Tiscar Graells, Koen F Dekkers, Gabriel Baldanzi, Diem Nguyen, Anders Larsson, Tobias Rudholm Feldreich, Nynne Nielsen, Aron C Eklund, Jacob B Holm, H Bjørn Nielsen, Göran Bergström, J Gustav Smith, Andrei Malinovschi, Gunnar Engström, Marju Orho-Melander, Tove Fall, Johan Ärnlöv

  • August 14, 2025

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