EBV-associated gastric carcinoma occurring one year after metabolic bariatric surgery: case report and literature review - Takeaways - MDSpire

EBV-associated gastric carcinoma occurring one year after metabolic bariatric surgery: case report and literature review

  • By

  • YingXin Wu

  • Xinxi Yang

  • Yuanyuan Chen

  • Bing Wang

  • Yanjun Liu

  • Tianqi Lu

  • July 1, 2026

  • 0 min

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  • 1

    A 62-year-old man developed Epstein-Barr virus-associated gastric carcinoma one year after single anastomosis sleeve ileal bypass surgery.

  • 2

    The patient was asymptomatic until a surveillance endoscopy revealed a 1.2 × 1.0 cm ulcer, leading to a biopsy-confirmed diagnosis of adenocarcinoma.

  • 3

    Postoperative pathological examination confirmed moderately to poorly differentiated EBV-associated gastric carcinoma with significant inflammatory cell infiltration.

  • 4

    Molecular testing identified an ARID1A truncating mutation and CCND1 amplification, while plasma EBV and circulating tumor DNA tests were negative.

  • 5

    The case suggests the need for routine gastroscopic assessment approximately one year after metabolic bariatric surgery to evaluate gastric mucosal health.

Original Source(s)

EBV-associated gastric carcinoma occurring one year after metabolic bariatric surgery: case report and literature review

  • by YingXin Wu, Xinxi Yang, Yuanyuan Chen, Bing Wang, Yanjun Liu, Tianqi Lu

  • July 1, 2026

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