Proteomic analysis of saliva reveals changes in proteomic profiles during colorectal cancer in an Iranian cohort - Takeaways - MDSpire

Proteomic analysis of saliva reveals changes in proteomic profiles during colorectal cancer in an Iranian cohort

  • By

  • Sama Rezasoltani

  • Ali Biabani

  • Bente Siebels

  • Hamid Asadzadeh Aghdaei

  • Georg Conrads

  • Hartmut Schlüter

  • Mohammad Mehdi Feizabadi

  • June 24, 2026

  • 0 min

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  • 1

    The study identified 181 salivary proteins with significantly different abundance between colorectal cancer (CRC) patients and non-cancer controls (NCCs).

  • 2

    Salivary proteomics demonstrated potential as a non-invasive method for early detection of CRC in an Iranian population.

  • 3

    Demographic analyses revealed protein abundance patterns varied by age, sex, and smoking status, yet some CRC-associated changes were consistent across subgroups.

  • 4

    Gene set enrichment analysis indicated suppression of cytoskeletal pathways and enrichment of protease regulatory pathways in CRC patients.

  • 5

    The study supports the role of salivary proteins in reflecting systemic tumor-immune interactions associated with early-stage CRC.

Original Source(s)

Proteomic analysis of saliva reveals changes in proteomic profiles during colorectal cancer in an Iranian cohort

  • by Sama Rezasoltani, Ali Biabani, Bente Siebels, Hamid Asadzadeh Aghdaei, Georg Conrads, Hartmut Schlüter, Mohammad Mehdi Feizabadi

  • June 24, 2026

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