Hand-foot skin reaction associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a FAERS-based pharmacovigilance study - Takeaways - MDSpire

Hand-foot skin reaction associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a FAERS-based pharmacovigilance study

  • By

  • Jinhan Chen

  • Qian Xu

  • Bozhou Wang

  • Huiwen Sun

  • Qijin Shu

  • June 4, 2026

  • 0 min

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  • 1

    Hand-foot skin reaction (HFSR) is a common and dose-limiting toxicity linked to VEGFR-TKIs, affecting treatment continuity and efficacy.

  • 2

    Analysis of 8,668 HFSR reports revealed eight VEGFR-TKIs with positive signals, particularly sorafenib and regorafenib.

  • 3

    The median time to HFSR onset was 16 days, with female patients experiencing earlier onset than male patients.

  • 4

    Hospitalization was the most frequently reported serious outcome associated with HFSR in patients treated with VEGFR-TKIs.

  • 5

    The study emphasizes the need for proactive monitoring during the initial weeks of therapy to manage HFSR effectively.

Original Source(s)

Hand-foot skin reaction associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a FAERS-based pharmacovigilance study

  • by Jinhan Chen, Qian Xu, Bozhou Wang, Huiwen Sun, Qijin Shu

  • June 4, 2026

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