Prepregnancy body mass index and risk of macrosomia after fresh embryo transfer: a retrospective cohort study with exploratory threshold analysis - Takeaways - MDSpire

Prepregnancy body mass index and risk of macrosomia after fresh embryo transfer: a retrospective cohort study with exploratory threshold analysis

  • By

  • Jing Wu

  • Ying Ju

  • Xiao He

  • Wanlin zhang

  • Fang Liu

  • Yuan Ma

  • Weiwei Kang

  • Man Di

  • Hengde Zhang

  • Jie Dong

  • Xiaohong Wang

  • July 15, 2026

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  • 1

    This study analyzed 2,195 women who underwent fresh embryo transfer to assess the impact of prepregnancy BMI on neonatal outcomes.

  • 2

    Higher prepregnancy BMI was associated with increased birthweight and a higher incidence of macrosomia in IVF-conceived pregnancies.

  • 3

    Macrosomia risk increased 2.25-fold for BMI 25-29.9 kg/m² and 4.56-fold for BMI ≥30 kg/m² compared to the reference group.

  • 4

    An exploratory BMI threshold of 26.22 kg/m² was identified, above which the odds of macrosomia significantly increased.

  • 5

    The findings suggest that a prepregnancy BMI exceeding 26 kg/m² may serve as a potential predictor for macrosomia risk in IVF pregnancies.

Original Source(s)

Prepregnancy body mass index and risk of macrosomia after fresh embryo transfer: a retrospective cohort study with exploratory threshold analysis

  • by Jing Wu, Ying Ju, Xiao He, Wanlin zhang, Fang Liu, Yuan Ma, Weiwei Kang, Man Di, Hengde Zhang, Jie Dong, Xiaohong Wang

  • July 15, 2026

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