Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients - Takeaways - MDSpire

Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients

  • By

  • Amrita Manchala

  • Eleni Maria Varypataki

  • Jehad Charo

  • Pablo Umaña

  • Christian Klein

  • Laura Codarri Deak

  • June 1, 2026

  • 0 min

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  • 1

    Eciskafusp alfa (PD1-IL2v) is engineered for targeted IL-2R agonism in PD-1+ cells, aiming to enhance anti-tumor responses.

  • 2

    The study shows increased PD-1 receptor density on tumor-infiltrating lymphocytes (TILs) compared to peripheral blood mononuclear cells (PBMCs).

  • 3

    PD1-IL2v preferentially targets stem-like and effector CD8+ TILs, resulting in superior biological activity over regulatory T cells.

  • 4

    Higher STAT5 phosphorylation in targeted CD8+ TILs confirms effective cis-targeting and enhanced IL-2R signaling by PD1-IL2v.

  • 5

    The findings suggest PD-1 receptor density and TIL subset prevalence as potential biomarkers for predicting patient responsiveness to PD1-IL2v.

Original Source(s)

Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients

  • by Amrita Manchala, Eleni Maria Varypataki, Jehad Charo, Pablo Umaña, Christian Klein, Laura Codarri Deak

  • June 1, 2026

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