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1
Lysine lactylation (Kla) is a novel post-translational modification that utilizes lactate to modify histones and non-histone proteins.
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2
Dysregulation of lactylation is linked to the pathogenesis of gynecological disorders, including cancers, endometriosis, and adverse pregnancy outcomes.
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3
Lactylation influences gene transcription, cellular metabolism, and immune microenvironment remodeling, impacting tumor progression and drug resistance.
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4
Therapeutic strategies targeting lactylation include modifying the enzymatic system and metabolic pathways, aiming for precision treatment in gynecological diseases.
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5
This review highlights the need for systematic research on lactylation's role in gynecological diseases and its potential for clinical application.
