Clinical Features and Prognostic Outcomes in Patients with Ocular Syphilis and HIV Co-Infection - Takeaways - MDSpire

Clinical Features and Prognostic Outcomes in Patients with Ocular Syphilis and HIV Co-Infection

  • By

  • Wenjun Kong

  • Fang Ruan

  • Lianyong Xie

  • Xia Feng

  • Yanqing Gao

  • Zhuyun Qian

  • Yong Tao

  • November 19, 2025

  • 0 min

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  • 1

    Ocular syphilis often coexists with HIV, affecting nearly half of the cases, complicating diagnosis and treatment.

  • 2

    The study involved 31 patients, primarily male and under 40, with a significant majority on highly active antiretroviral therapy.

  • 3

    Common ocular manifestations included acute syphilitic posterior placoid chorioretinitis and optic neuritis, with varying visual outcomes.

  • 4

    Mean visual acuity improved significantly after treatment, with baseline LogMAR BCVA of 1.08 improving to 0.86 post-treatment.

  • 5

    Vitreous opacity and macular involvement were prevalent in 88.1% and 69.0% of eyes, respectively, with optic neuritis showing lower macular involvement.

Original Source(s)

Clinical Features and Prognostic Outcomes in Patients with Ocular Syphilis and HIV Co-Infection

  • by Wenjun Kong, Fang Ruan, Lianyong Xie, Xia Feng, Yanqing Gao, Zhuyun Qian, Yong Tao

  • November 19, 2025

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