Concordant ETV6::RUNX1-positive acute lymphoblastic leukemia in monozygotic twins: a case report and review of the literature - Takeaways - MDSpire

Concordant ETV6::RUNX1-positive acute lymphoblastic leukemia in monozygotic twins: a case report and review of the literature

  • By

  • Xiaohua Li

  • Cuicui Wang

  • Jianchang Li

  • Chaoyue Liu

  • Weimei Sun

  • Yanjun Zhang

  • Jian Shi

  • June 18, 2026

  • 0 min

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  • 1

    Both monozygotic twins were diagnosed with acute lymphoblastic leukemia, testing positive for the ETV6::RUNX1 fusion gene.

  • 2

    Patient A was diagnosed with Common B-ALL, while Patient B was diagnosed with Pre-B-ALL, both classified as low risk.

  • 3

    Both patients received chemotherapy according to the CCLG-ALL-2018 protocol and achieved complete remission after treatment.

  • 4

    The twins have remained in continuous complete remission for over 2 years following the completion of their chemotherapy.

  • 5

    This case supports the hypotheses regarding the in utero origin and two-hit mechanisms in the development of pediatric acute lymphoblastic leukemia.

Original Source(s)

Concordant ETV6::RUNX1-positive acute lymphoblastic leukemia in monozygotic twins: a case report and review of the literature

  • by Xiaohua Li, Cuicui Wang, Jianchang Li, Chaoyue Liu, Weimei Sun, Yanjun Zhang, Jian Shi

  • June 18, 2026

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