Association of Lower Serum Sclerostin Levels With Elevated Risk for Increased Arterial Stiffness: The JPOS Cohort Study - Takeaways - MDSpire

Association of Lower Serum Sclerostin Levels With Elevated Risk for Increased Arterial Stiffness: The JPOS Cohort Study

  • By

  • Junko Tamaki

  • Takahiro Tachiki

  • Myadagmaa Jaalkhorol

  • Namiraa Dongmei

  • Misa Komastu

  • Kouji Tsuda

  • Asako Kudo

  • Kuniyasu Kamiya

  • Katsuyasu Kouda

  • Etsuko Kajita

  • Sadanobu Kagamimori

  • Masayuki Iki

  • November 12, 2024

  • 0 min

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  • 1

    Lower serum sclerostin levels are linked to a higher risk of increased arterial stiffness in Japanese women aged 50 and older.

  • 2

    The study analyzed 662 women, with 556 participating in a 4- to 5-year follow-up, revealing significant findings on arterial stiffness.

  • 3

    Increased arterial stiffness rates were 22.2%, 16.1%, and 12.4% for low, medium, and high tertiles of sclerostin, respectively.

  • 4

    Odds ratios indicated that women in the low tertile had a 2.50 times higher risk of increased arterial stiffness after adjustments.

  • 5

    The findings suggest that sclerostin may play a role in vascular health, potentially influencing cardiovascular disease risk.

Original Source(s)

Association of Lower Serum Sclerostin Levels With Elevated Risk for Increased Arterial Stiffness: The JPOS Cohort Study

  • by Junko Tamaki, Takahiro Tachiki, Myadagmaa Jaalkhorol, Namiraa Dongmei, Misa Komastu, Kouji Tsuda, Asako Kudo, Kuniyasu Kamiya, Katsuyasu Kouda, Etsuko Kajita, Sadanobu Kagamimori, Masayuki Iki

  • November 12, 2024

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