Differential infiltration of CD4+ and CD8+ T cells and expression of PD-L1 in paired biopsy and resection specimens of gastric and colorectal adenocarcinomas - Takeaways - MDSpire

Differential infiltration of CD4+ and CD8+ T cells and expression of PD-L1 in paired biopsy and resection specimens of gastric and colorectal adenocarcinomas

  • By

  • Wang, Zi-xuan

  • Zhang, Chun-mei

  • Liu, Yao-zhen

  • Zhang, Yu-wei

  • Tong, Shi-jie

  • Liu, Qi

  • Deng, Duo

  • Pan, Yun

  • June 22, 2026

  • 0 min

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  • 1

    The study compared CD4+ and CD8+ T cell infiltration and PD-L1 expression in biopsy and resection specimens of gastric and colorectal adenocarcinomas.

  • 2

    In gastric adenocarcinoma, resection specimens exhibited significantly higher CD4+ T cell, CD8+ T cell density, and PD-L1 expression compared to biopsies.

  • 3

    In colorectal adenocarcinoma, only CD8+ T cell density was significantly higher in resection specimens, while CD4+ T cells negatively correlated with Ki-67.

  • 4

    CD4+/CD8+ ratios were positively correlated at the tumor center and invasive margin in both gastric and colorectal cancers.

  • 5

    The study concluded that biopsy specimens inadequately represent the immune microenvironment of resection specimens, particularly in gastric adenocarcinoma.

Original Source(s)

Differential infiltration of CD4+ and CD8+ T cells and expression of PD-L1 in paired biopsy and resection specimens of gastric and colorectal adenocarcinomas

  • by Wang, Zi-xuan , Zhang, Chun-mei , Liu, Yao-zhen , Zhang, Yu-wei , Tong, Shi-jie , Liu, Qi , Deng, Duo , Pan, Yun

  • June 22, 2026

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