Spatially microdissected profiling of tonsillar germinal centers reveals a KLRG1-enriched immune signature in IgA nephropathy - Takeaways - MDSpire

Spatially microdissected profiling of tonsillar germinal centers reveals a KLRG1-enriched immune signature in IgA nephropathy

  • By

  • Mayuko Kawabe

  • Izumi Yamamoto

  • Yutaro Ohki

  • Ayaka Hayashi

  • Go Kanzaki

  • Kei Matsumoto

  • Hiroyuki Ueda

  • Keita Hirano

  • Nobuo Tsuboi

  • Takashi Yokoo

  • May 22, 2026

  • 0 min

Share

  • 1

    This study analyzed tonsils from patients with IgA nephropathy and habitual tonsillitis to explore immune profiles in the germinal center.

  • 2

    IgAN tonsils exhibited a KLRG1-enriched immune signature, with significant upregulation of KLRG1 and ZBTB16 compared to controls.

  • 3

    Immunohistochemistry confirmed KLRG1 localization in germinal centers of IgAN cases, particularly in those with crescentic glomerular lesions.

  • 4

    The study suggests a potential link between KLRG1 expression in germinal centers and the severity of glomerular injury in IgAN.

  • 5

    Findings indicate that the immune architecture of tonsillar germinal centers may differ significantly between IgAN and habitual tonsillitis.

Original Source(s)

Spatially microdissected profiling of tonsillar germinal centers reveals a KLRG1-enriched immune signature in IgA nephropathy

  • by Mayuko Kawabe, Izumi Yamamoto, Yutaro Ohki, Ayaka Hayashi, Go Kanzaki, Kei Matsumoto, Hiroyuki Ueda, Keita Hirano, Nobuo Tsuboi, Takashi Yokoo

  • May 22, 2026

Related Content

Psychological distress among dialysis patients during the COVID-19 Omicron pandemic: risk and protective factors across hemodialysis and peritoneal dialysis

A case of severe psittacosis in a hemodialysis patient—the critical role of detailed medical history and next-generation sequencing

Plasma PZP level elevation: a potential correlate of diabetic kidney disease progression