Evaluating the Prognostic Nutritional Index in Renal Cell Carcinoma Patients: A Comprehensive Systematic Review and Meta-Analysis Update - Takeaways - MDSpire

Evaluating the Prognostic Nutritional Index in Renal Cell Carcinoma Patients: A Comprehensive Systematic Review and Meta-Analysis Update

  • By

  • Zhuo Xu

  • Leihong Xie

  • Hanchao Zhang

  • Guanghui Han

  • Weiquan Guo

  • February 14, 2026

  • 0 min

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  • 1

    Renal cell carcinoma (RCC) is a prevalent malignancy, contributing significantly to cancer-related mortality worldwide.

  • 2

    The prognostic nutritional index (PNI) combines serum albumin and lymphocyte count, reflecting nutritional and immune status in cancer patients.

  • 3

    Lower PNI values are associated with poor survival outcomes in RCC, linked to higher tumor stage and grade.

  • 4

    This systematic review and meta-analysis aims to evaluate the prognostic significance of PNI in RCC, incorporating recent studies and larger sample sizes.

  • 5

    The study seeks to clarify PNI's role as an independent prognostic factor and its potential for personalized treatment in RCC patients.

Original Source(s)

Evaluating the Prognostic Nutritional Index in Renal Cell Carcinoma Patients: A Comprehensive Systematic Review and Meta-Analysis Update

  • by Zhuo Xu, Leihong Xie, Hanchao Zhang, Guanghui Han, Weiquan Guo

  • February 14, 2026

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