Myocardial work abnormalities in rheumatoid arthritis with preserved left ventricular ejection fraction are more closely related to disease activity than to disease duration: a prospective cross-sectional study - Takeaways - MDSpire

Myocardial work abnormalities in rheumatoid arthritis with preserved left ventricular ejection fraction are more closely related to disease activity than to disease duration: a prospective cross-sectional study

  • By

  • Xiaolong Yu

  • Yanjia Lu

  • Jing Xi

  • Mingsi Wang

  • Junli Chen

  • Ruixiao Song

  • July 6, 2026

  • 0 min

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  • 1

    The study enrolled 59 rheumatoid arthritis patients with preserved left ventricular ejection fraction to assess subclinical left ventricular dysfunction.

  • 2

    Myocardial work analysis revealed impaired myocardial mechanics in both RA groups compared to healthy controls, with significant reductions in GLS, GWI, and GCW.

  • 3

    Global work efficiency was negatively correlated with inflammatory activity, indicating a relationship between current disease activity and myocardial function.

  • 4

    No significant correlation was found between myocardial work parameters and disease duration, suggesting current inflammation is a more critical factor.

  • 5

    The findings support the use of myocardial work analysis as a sensitive tool for identifying subclinical myocardial impairment in rheumatoid arthritis patients.

Original Source(s)

Myocardial work abnormalities in rheumatoid arthritis with preserved left ventricular ejection fraction are more closely related to disease activity than to disease duration: a prospective cross-sectional study

  • by Xiaolong Yu, Yanjia Lu, Jing Xi, Mingsi Wang, Junli Chen, Ruixiao Song

  • July 6, 2026

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