Development and validation of a pre-chemotherapy nomogram integrating systemic immune-inflammation index and prognostic nutritional index to predict severe adjuvant toxicity in colorectal cancer - Takeaways - MDSpire

Development and validation of a pre-chemotherapy nomogram integrating systemic immune-inflammation index and prognostic nutritional index to predict severe adjuvant toxicity in colorectal cancer

  • By

  • Wenjing Li

  • Hua Zhang

  • Jie Wu

  • Liyan Jin

  • May 11, 2026

  • 0 min

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  • 1

    The study developed a nomogram using pre-chemotherapy SII and PNI to predict severe chemotherapy-induced toxicity in stage II/III colorectal cancer patients.

  • 2

    Severe chemotherapy-induced toxicity occurred in 25.5% of patients, with high SII and low PNI identified as independent risk factors for adverse events.

  • 3

    The nomogram demonstrated excellent discrimination and calibration, with an apparent AUC of 0.868 and a Brier score of 0.1114.

  • 4

    High-risk patients experienced significantly shorter therapy durations and lower oxaliplatin dose intensity compared to low-risk patients.

  • 5

    The nomogram offers a reliable, cost-effective tool for risk stratification, enabling personalized management strategies for high-risk colorectal cancer patients.

Original Source(s)

Development and validation of a pre-chemotherapy nomogram integrating systemic immune-inflammation index and prognostic nutritional index to predict severe adjuvant toxicity in colorectal cancer

  • by Wenjing Li, Hua Zhang, Jie Wu, Liyan Jin

  • May 11, 2026

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