Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID - Takeaways - MDSpire

Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID

  • By

  • Benjamin Orlinick

  • Sameet Mehta

  • Lindsay McAlpine

  • Saba Khoshbakht

  • Sofia Fertuzinhos

  • Allison Nelson

  • Jennifer Chiarella

  • Bibhuprasad Das

  • Vansh Patel

  • Paraskevas Filippidis

  • Michael J Corley

  • Serena S Spudich

  • Shelli F Farhadian

  • September 8, 2025

  • 0 min

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  • 1

    Women are disproportionately affected by neuropsychiatric symptoms following recovery from acute COVID-19.

  • 2

    The study analyzed gene expression in cerebrospinal fluid and peripheral blood mononuclear cells of women with NP-Long COVID.

  • 3

    CSF samples showed specific gene expression changes related to oxidative stress and cellular stress pathways in Long COVID.

  • 4

    Dysregulated pathways in both CSF and PBMC included those related to androgen response, MTORC1 signaling, and lipid metabolism.

  • 5

    The findings highlight the need for examining CSF-specific molecular profiles to understand post-viral neurological syndromes.

Original Source(s)

Cerebrospinal Fluid Immune Cell Alterations in Women With Neuropsychiatric Long COVID

  • by Benjamin Orlinick, Sameet Mehta, Lindsay McAlpine, Saba Khoshbakht, Sofia Fertuzinhos, Allison Nelson, Jennifer Chiarella, Bibhuprasad Das, Vansh Patel, Paraskevas Filippidis, Michael J Corley, Serena S Spudich, Shelli F Farhadian

  • September 8, 2025

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