Caspases and programmed cell death in sepsis: mechanisms, pathophysiology, and therapeutic targets - Takeaways - MDSpire

Caspases in Sepsis: Understanding Programmed Cell Death Mechanisms, Pathophysiology, and Potential Therapeutic Approaches

  • By

  • Haibei He

  • Xiuli Xie

  • Lisui Zhou

  • Yumeng Lin

  • Aijun Liu

  • Peng Guo

  • Yu Zhu

  • Yu Tang

  • Zhongyu Han

  • Yi Wang

  • Haoran Chen

  • July 17, 2026

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  • 1

    Sepsis is a critical condition marked by organ impairment due to an uncontrolled systemic reaction to infection.

  • 2

    Caspases are central to programmed cell death mechanisms, regulating apoptosis, necroptosis, pyroptosis, and PANoptosis.

  • 3

    Dysregulated programmed cell death contributes to immune dysregulation and organ damage in sepsis.

  • 4

    Sepsis-related mortality increased to 21.4 million cases in 2021, partly due to COVID-19, reversing previous declines.

  • 5

    Understanding caspase regulation is essential for developing targeted therapies for sepsis.

Original Source(s)

Caspases and programmed cell death in sepsis: mechanisms, pathophysiology, and therapeutic targets

  • by Haibei He, Xiuli Xie, Lisui Zhou, Yumeng Lin, Aijun Liu, Peng Guo, Yu Zhu, Yu Tang, Zhongyu Han, Yi Wang, Haoran Chen

  • July 17, 2026

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